7 Dec 2011 Salinomycin (see Figure 2) is a carboxylic polyether ionophore Salinomycin and its salts exist in a pseudo‐cyclic structure because of the 

Eimeria spp is the largest coccidial species in poultry. it is considered as a main causal agent of coccidiosis in poultry.

The results indicated that the stereoscopic configurations of the spiro C17 and C21 atoms as well as the … Abstract The ionophore salinomycin has attracted attention for its exceptional ability to selectively reduce the proportion of cells with stem‐like properties in cancer cell populations of varying Salinomycin Hydroxamic Acids: Synthesis, Structure, and Biological Activity of Polyether Ionophore Hybrids By Björn Borgström, Xiaoli Huang, Eduard Chygorin, Stina Oredsson and Daniel Strand Cite The ionophore salinomycin exerts selective activity against cancer stem cells. Synthetic strategies for modification of the directly accessible functional groups of this structure are explored, and a set of activity domains are identified by biological assays. Salinomycin has a high affinity for monovalent cations, p articularly potassium. Recently, salinomycin has been shown to inhibit cancer stem cells.

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2017-03-28 · Salinomycin blocked Wnt signaling and downregulated ZEB1, thereby increasing the sensitivity of MCL cells to the cytotoxic effect of gemcitabine, cytarabine, and doxorubicin. 70 In combination with metformin, salinomycin was able to block TGFβ-induced EMT and inhibit EMT-induced cell migration in the two non-small-cell lung cancer cell lines A549 and HCC4006. 71 Salinomycin inhibited File:Salinomycin-structure.png. From Wikimedia Commons, the free media repository.

PDF | On Oct 15, 1975, H. Kinashi and others published Studies on the ionophorous antibiotics. I. The crystal and molecular structure of salinomycin p-iodophenacyl ester | Find, read and cite all

Salinomycin' is a new antibiotic elaborated by the strain of Streptomyces aZbus and has an antimicrobial activity against Gram-positive bacteria, mycobacteria and fungi. Furthermore, salinomycin is effective in the treatment of coccidial infections in poultry. In light of its biological activity coupled with the physicochemical properties and spectral data, the antibiotic is assumed to belong This information is only displayed if the substance is well-defined, its identity is not claimed confidential and there is sufficient information available in ECHA’s databases for ECHA’s algorithms to generate a molecular structure.

2019-11-13 · Salinomycin counteracts the proliferation of uveal melanoma cells. a Chemical structure of salinomycin. b Uveal melanoma (UM) cells and ARPE-19 cells were treated with a gradient concentrations of salinomycin for 72 h, and the cell viability was measured by MTS assay.

The twelve carbonyl groups are essential for the binding of metal ions, and also for solvation in polar solvent. The isopropyl and methyl groups are responsible for solvation in nonpolar solvents. Identification. Name. Salinomycin. Synonyms. (2R)-2- ( (5S)-6- {5- [ (10S,12R)-2- ( (6S,5R)-5-Ethyl-5-hydroxy-6-methylperhydro-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro [4.1.5.3]pentadec-13-en-9-yl] (1S,2S,3S,5R)-2-hydroxy-1,3-dimethyl-4-oxoheptyl}-5-methylperhydro-2H-pyran-2-yl)butanoic acid.

Availability: In stock. Salinomycin diastereoisomers and their benzoylated derivatives were synthesized and evaluated for both antiproliferative activity and neurotoxicity in vitro.The results indicated that the stereoscopic configurations of the spiro C17 and C21 atoms as well as the benzoyl groups of O-20 on the rigid B/C/D spiro-ketal structures are crucial for biological activity and neural toxicity. Abstract.
Johan sjöstrand

Conclusions: Synthetic structural analogs of salinomycin, previously shown to exhibit Structure-activity relationship within a series of okadaic acid derivatives. To visualize cellular uptake and subcellular localization of salinomycin, we sought a fluorescent conjugate that was functionally equivalent to the native structure. An active fluorescent salinomycin conjugate reveals rapid cellular uptake and a fluorescent conjugate that was functionally equivalent to the native structure. Bushnell, F. Salinomycin as a drug for targeting human cancer stem cells.

Chemical Structure. Molecular Weight. Drug & Food Interactions. Target Sequences.
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Salinomycin (Procoxacin) Chemical Structure. CAS NO. 53003-10-4. Salinomycin (Procoxacin) is an antibacterial and coccidiostat ionophore therapeutic agent.

Salinomycin. Synonyms.

15 Jan 2021 This curcumin and salinomycin co-delivery system can be an efficient treatment Solid-state and solution structure of the salinomycin–sodium 

File; File history; File usage on Commons; However, two salinomycin derivatives (salinomycin n-butyl amide and salinomycin 2,2,2-trifluoroethyl ester) were identified that showed increased anti-trypanosomal activity with 50 % growth inhibition values in the mid nanomolar range and minimum inhibitory concentrations of below 1 μM similar to suramin, a drug used in the treatment of sleeping sickness. Salinomycin sodium salt Chemical Structure.

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